3-iodo-5-broMo-1H-pyrazolo[3,4-b]pyridine

3-iodo-5-broMo-1H-pyrazolo[3,4-b]pyridine - Names and Identifiers

Name	5-bromo-3-iodo-1H-pyrazolo[5,4-b]pyridine
Synonyms	LogP 5-Bromo-3-iodo-1H-pyrazol... 5-broMo-3-iodo-1H-pyrazolo[3 2-bromo-7-iodo-5H-pyrrolo[3,2-b]pyrazine 5-bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine 3-iodo-5-broMo-1H-pyrazolo[3,4-b]pyridine 5-bromo-3-iodo-2H-pyrazolo[3,4-b]pyridine 5-bromo-3-iodo-1H-pyrazolo[5,4-b]pyridine 5-broMo-3-iodo-1H-pyrazolo[3,4-b]pyrazine 1H-Pyrazolo[3,4-b]pyridine,5-bromo-3-iodo- 1H-pyrazolo[3,4-b]pyridine, 5-bromo-3-iodo-
CAS	875781-18-3
InChI	InChI=1/C6H3BrIN3/c7-3-1-4-5(8)10-11-6(4)9-2-3/h1-2H,(H,9,10,11)
InChIKey	ZBPXFBHBTCYAQS-UHFFFAOYSA-N

3-iodo-5-broMo-1H-pyrazolo[3,4-b]pyridine - Physico-chemical Properties

Molecular Formula	C6H3BrIN3
Molar Mass	323.92
Density	2.559
Boling Point	409.1±40.0 °C(Predicted)
Flash Point	201.2°C
Vapor Presure	1.57E-06mmHg at 25°C
pKa	6.70±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.824

3-iodo-5-broMo-1H-pyrazolo[3,4-b]pyridine - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
WGK Germany	3
Hazard Class	IRRITANT

3-iodo-5-broMo-1H-pyrazolo[3,4-b]pyridine - Reference Information

application

5-bromo-3-iodo-1H-pyrazolo [3,4-B] pyrimidine can be used as an intermediate in organic synthesis and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical generation processes.

Preparation

Compound 3-iodo-1H-pyrazolo [3,4-B] pyrimidine diazonium salt is dissolved in chloroform solution, and then slowly Drop the bromine and keep the temperature at 40°C. After dropping, add heat and reflux for 6 hours, after cooling to room temperature, slowly drop a saturated sodium bicarbonate solution under an ice bath to quench the reaction, add dichloromethane, extract the reaction liquid, stand for stratification, collect the organic phase, wash the water phase many times, after combining the organic phase, add anhydrous sodium sulfate to dry, concentrate the organic phase, and obtain the compound 5-bromo-3-iodo-1H-pyrazolo [3,4-B] pyrimidine.

Last Update：2024-04-10 22:29:15